The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic ß cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics incl.
Isotopes in Biochemistry, Foreword, Contents, Opening Address, Part I-Steroids, Metabolism of 14C-labelled steroids, High cholesterol content of human spleen, The biosynthesis of radioactive cholesterol br surviving liver slices, Studies with deuterium steroids, Part II-Hbmoglobin and Metabolic Derivatives, The biosynthetic mechanism of porphyrin formation, Studies on mammaIian red cells, Preliminary investigations for a study of energy utilized by the surviving fowl erythrocyte in hsem synthesis, Iron metabolism in pathological conditions.